NettetResearchers speculated in the press that the legacy effect may work more for middle-aged men than for the elderly. It appears that starting a statin regimen at age 50 or so and taking the pills daily for 5 years is enough to have a lasting benefit. Even if you stop taking the medicine, your risk of CVD is lowered when you are 75 years old. Nettetacute withdrawal of statin may increase stiffness in the carotid artery, possibly having a deleterious effect on recurrent vascular events in high cardiovascular risk patients. To reiterate the importance of main-taining statin medication, Kim et al.9 set out to assess the changes in carotid Legacy Effect of Statin Should Not Be Discontinued
The “Legacy Effect” in Diabetes – The Long-Term Benefits of …
Nettet1. okt. 2024 · On the flip side, a recent study by Odden et al. estimated that any statin-related adverse effect that contributes to a mild decline in functioning and cognition may counterbalance its cardiovascular benefits in primary prevention in older adults (>75 years). 9 Moreover, there is a consideration of the competing risk from non-ASCVD … Nettet30. des. 2016 · Legacy effect of statins: 20-year follow up of the West of Scotland Coronary Prevention Study (WOSCOPS). ... Impact on statin therapy-European … sizing a steam shower
The Legacy Effect in the Prevention of Cardiovascular Disease
Nettet21. jun. 2024 · Whilst it has long been recognized that reported rates of adverse effects of statin therapy are greater in open label than randomized trials (a fact strongly suggestive of the nocebo effect), the absolute proportion of adverse effects caused by nocebo has been hard to quantify. 5 Two recent trials have shed light on the issue (Table 1), and … Nettet13. jan. 2015 · This legacy effect, he added, can be viewed as an ongoing carryover effect related to statin-induced slowing and/or stabilization of existing coronary artery plaque. The mechanism is unknown, Dr. White said, but the key to why the legacy effect was seen in WOSCOPS despite the use of pravastatin ... Nettet31. aug. 2024 · Lowering cholesterol along with blood pressure in patients with hypertension has a lasting impact on survival years after medications have been stopped, new long-term data from the ASCOT Legacy … sizing a softball bat for youth